The TB-500 peptide is a typical veterinary preparation used to prevent adhesions in race horses. This peptide is a synthetic version of Thymosin Beta 4, and the peptide segment (17)LKKT ETQ(23) is its primary component.
However, this segment is also the region in Thymosin Beta 4 and is entirely responsible for binding with actin. Thus, it deliberately exhibits typical effects like wound healing, angiogenesis, and cell migration.
Today, this article will discuss and elaborate on the functional benefits of TB-500. Please keep reading until the end to know more about the same.
Thymosin Beta 4 is a typically natural protein found in humans and is encoded by the TMSB4X gene. However, the World Health Organization has published this natural protein as Timbetasin. It comprises 43 amino acids and has a molecular weight of 4,921 g/mol.
This natural protein is regenerative, water-soluble, and is typically found in all types of cells and tissues. Furthermore, even though it is not present in red blood cells, it can be found in almost every other body fluid. Some of them include saliva, tears, wound fluids, and also cerebrospinal fluid.
Thymosin Beta 4 is a major G-actin-sequestering peptide found in mammals. It has magnificent biological effects, including the formation of blood vessels and the promotion of angiogenesis. It also provides aid in cell survival, cell migration, modulation of chemokines and cytokines, and stem cell differentiation.
Various studies involving TB-500 have revealed a wide range of effects offered by this synthetic peptide. Some of them include endothelial cell differentiation, promoting angiogenesis, keratinocyte migration, anti-inflammatory effects, collagen deposition, etc.
In a nutshell, TB-500 and Thymosin Beta 4 has almost similar effects technically. It’s because the former is nothing but an isolated active region of the latter.
Here, we have listed some of the functional benefits associated with TB-500 (Thymosin Beta 4):
Numerous tissue culture studies have revealed that TB-500 (Thymosin Beta 4) promotes re-epithelialization, cell migration, blood vessel formation, angiogenesis, etc. Moreover, fortunately, these effects are immensely crucial for repairing and regeneration of tissues.
TB-500 (Thymosin Beta 4) typically forms a complex with the Globular actin. These monomers further go on to polymerize with each other, thereby formulating the F-actin or Filamentous actin. Moreover, these actins, along with several other actin-binding proteins, form cellular microfilaments.
While TB-500 (Thymosin Beta 4) can re-epithelialization and cell migration, it can help wound healing. Furthermore, most importantly, its anti-microbial property prevents microbial infection at the wound sites, which would otherwise damage the tissues.
If you are willing to conduct further research with TB-500, you can purchase this peptide from Loti Labs. As they are USA-made peptides, they will ensure the integrity of any clinical study or research. Besides, they sell TB-500 after testing through HPLC and Mass spectrometry, thereby ensuring purity and top-notch quality. This peptide is available in lyophilized powder form and is commonly sold in 5gm vials.